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The oral intake of glutathione has always been the limiting factor** for its use in food supplements: the human intestine contains significant quantities of the enzyme gamma-glutamyltranspeptidase, responsible for the degradation of glutathione after oral ingestion

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These interventions are particularly relevant to antigen processing and presentation, DC priming and early T cell activation, because they modulate the availability of immunologically critical amino acids or reduce suppressive metabolites in the TME