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Activated adipocytes produce an array of vascular growth factors, including vascular endothelial growth factor (VEGF), VEGF-C, VEGF-D, soluble VEGF receptor-2 (sVEGFr2), hepatocyte growth factor (HGF), angiopoietin-2, and angiogenin, and serum concentrations of several of these growth factors are higher in overweight and obese individuals