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Endotoxemia Lipopolysaccharide (LPS) is a major component of the outer membrane of all gram-negative bacteria that can trigger the synthesis and release of pro-inflammatory cytokines such as TNFα, interleukin 1β (IL-1β), and inducible nitric oxide synthase (iNOS) (Zhang et al., 2000

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Genetics 120 , 1061–1072 (1988)