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Afatinib, the first covalent inhibitor of EGFR approved by the FDA, binds to Cys797 residue on the kinase domain of EGFR in the “DFG-in” conformation (94)

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These factors predominantly include the frequent consumption of sugar-sweetened beverages, ultra-processed foods, and diets high in saturated fats, which promote weight gain and chronic low-grade inflammation (158)