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The absence of IL31 and NGF mRNA in leukocytes from the volunteers suggests that the proteins they encode, which were previously found to be elevated in the plasma samples of patients with VCD during the recruitment appointment four months after mild acute COVID-19 4 , might be primarily produced by other cell types 40,41,42

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Meanwhile, overexpression of Bmal1 and Clock may activate HIF-1α, involved in the regulation of innate neuroprotection (Lembach et al., 2018)