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Its water‑soluble, ≥ 95 % purity formulation and short plasma half‑life (7–8 minutes) allow rapid crossing of the blood‑brain barrier, where it enhances delta‑wave (slow‑wave) activity— the deepest stage of restorative sleep DSIP is a nonapeptide (Trp‑Ala‑Gly‑Gly‑Asp‑Ala‑Ser‑Gly‑Glu) first isolated from rabbit brain and produced in the human hypothalamus

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Teichman SL, et al