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(2012) using microarray analysis on human fibroblasts revealed that GHK can upregulate genes associated with ECM synthesis, such as collagen and elastin, while downregulating genes for matrix metalloproteinases (MMPs), which are enzymes that degrade ECM components

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The predominant anion form (II) , at physiological pH, is expected to be oxidized by the molecular oxygen to form reactive oxygen species (O 2 •− , H 2 O 2 and HO • )