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Glucagon itself generally raises glucose, but potent incretin-based therapies can lower glucose substantially, especially when combined with insulin or sulfonylureas

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According to the Semaglutide Treatment Effect in People with Obesity (STEP) program studies, people with overweight or obesity (without T2DM) who received semaglutide 2.4 mg and underwent lifestyle interventions experienced an average weight reduction of 14.7- 17.4% [116]

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